https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34508 Wed 20 Mar 2019 10:26:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29991 18F-FDG PET-CT performed before definitive radiation therapy (RT) (prePET) in patients with mucosal primary head and neck squamous cell carcinoma (MPHNSCC) and to assess the additive prognostic values of FDG PET-CT performed during RT (iPET). Methods: One hundred patients with MPHNSCC treated with radical RT underwent staging prePET and iPET performed during the third week of treatment. The maximum standardized uptake value (SUV_max), metabolic tumour volume (MTV) and total lesional glycolysis (TLG) of primary tumour were analysed for both prePET and iPET, and results were correlated with loco-regional recurrence-free survival (LRFS), disease-free survival (DFS), metastatic failure-free survival (MFFS) and overall survival (OS), using Kaplan–Meier analysis. Optimal cut-offs (OC) for prePET and iPET were derived from Receiver Operating Characteristic curves. Patients with metabolic parameters above/below the individual OC of prePET as well as iPET (i.e. combined prePET and iPET (comPET)) were evaluated against their outcomes. Results: Median age was 61 years (range 39–81), median follow-up of 20 months (range 4–70, mean 27), and AJCC 7th Edition clinical stage II, III and IV were 8, 24 and 68 patients respectively. Metabolic values below individual OC in comPET were found to be associated with statistically significant improvements (P < 0.05) in DFS, LRFS and OS. In addition, patients with SUV_max above the OC in comPET were associated with worse MFFS (P = 0.011) and confirmed on both univariate (P = 0.019) and multivariate analyses (P = 0.04). Conclusion: Addition of iPET significantly improves the prognostic values of all three metabolic parameters and can potentially be used in future adaptive local and systemic therapy trials.]]> Thu 28 Oct 2021 12:36:43 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45129 Thu 27 Oct 2022 10:56:54 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7557 Sat 24 Mar 2018 08:42:05 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18806 0.05). Higher incidence of significant blood spillage during the procedure was observed among clinicians wearing no gloves (16.74%) in comparison with their glove-wearing counterparts (9.03%, P < 0.05). One needlestick injury was recorded in the present study period. There was no difference in blood culture contamination rate between glove-wearing group and no-gloves group (3.94% vs 3.76%, P > 0.05). Conclusions: The present study shows that the use of protective gloves was not associated with adverse outcomes of clinical performance during paediatric cannulation. The low compliance rate of gloves use is alarming, and many clinicians might be exposed to potential blood-borne infections. Clinicians should be encouraged and supported to use gloves for paediatric cannulation.]]> Sat 24 Mar 2018 07:51:04 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53033 Mon 13 Nov 2023 08:48:28 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52300 Mon 09 Oct 2023 10:17:40 AEDT ]]>